Certain medications, such as statins, can cause increases in CPK, so be sure to tell your doctor about any medications you currently take. All information contained within the Johns Hopkins Lupus Center website is intended for educational purposes only.
Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained within this site. Some people feel only a prick or stinging sensation. Afterward, there may be some throbbing. CPK isoenzyme testing can help find the exact source of the damaged tissue. Increased CPK-1 levels may be due to:. CPK-2 levels rise 3 to 6 hours after a heart attack. If there is no further heart muscle damage, the level peaks at 12 to 24 hours and returns to normal 12 to 48 hours after tissue death.
Higher-than-normal CPK-3 levels are most often a sign of muscle injury or muscle stress. They may be due to:. Factors that can affect test results include cardiac catheterization , intramuscular injections, recent surgery, and vigorous and prolonged exercise or immobilization. Habib G. In: Harward MP, ed. Medical Secrets. Philadelphia, PA: Elsevier; chap 4. Plasma proteins and enzymes. Clinical Chemistry. St Louis, MO: Elsevier; chap Panteghini M, Bais R.
Philadelphia, PA: Elsevier; chap Hamel J, Statland JM. Muscle disease. Cecil Essentials of Medicine. Mccullough PA. Interface between renal disease and cardiovascular illness.
Clinical enzymology. Reviewed by: Thomas S. Editorial team. Creatine phosphokinase test CPK test. How the Test is Performed A blood sample is needed. This test may be repeated over 2 or 3 days if you are a patient in the hospital. When these parts of your body become damaged due to injury or disease, CPK enzymes can be released into your bloodstream. The CPK isoenzymes test checks the levels of these enzymes in your blood. This can help your doctor identify the areas of your body that have been damaged.
The CPK isoenzymes test is a simple blood test that involves minimal preparation and risk. The blood sample will be sent to a laboratory for analysis, and your doctor will explain the results to you. The CPK isoenzymes test may still be used in some cases, but over the past decade, most doctors have transitioned away from it.
Instead, a troponin test is often performed to evaluate damage to your heart muscle. A troponin test measures the levels of proteins called troponin T and troponin I in the blood. These proteins are released when your heart muscle becomes damaged due to a heart attack or other serious heart condition. The troponin test procedure is similar to that of a CPK isoenzymes test.
A CPK isoenzymes test is usually done in the emergency room if you have the symptoms of a heart attack. Your doctor may order a CPK blood test to:. The test can also determine whether you carry the gene for muscular dystrophy. Muscular dystrophy is a group of diseases that causes muscle loss and weakness over time. A CPK isoenzymes test can detect various muscle diseases or issues, including:. The CPK isoenzymes test is similar to other blood tests. Some substances can cause elevated CPK, including:.
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